On Two Cases of Multiple Cartilaginous Exostosis

Hereditary multiple exostosis.

Hereditary multiple exostosis is an intriguing genetic condition with a clinical impact in the field of orthopaedics, paediatrics and oncology. In this review we highlight the current knowledge about this condition from a clinical and scientific point of view. This gives us more insight into the molecular mechanisms and current models on which therapeutic agents are based. It allows for a multi...

Seven Cases of Diaphysial Aclasis (Multiple Exostosis) in Indians, Including Four Cases from One Family

Multiple cartilaginous exostosis in a Golden Retriever cross-bred puppy. Clinical, radiographic and backscattered scanning microscopy findings.

Multiple cartilaginous exostosis was diagnosed in a six-month-old Golden Retriever cross-bred male with a history of forelimb lameness and isolated, but very painful, acute episodes. Physical examination revealed a right forelimb lameness with a firm, painful palpable mass on the cranial aspect of the forearm. The radiological examination showed the presence of bony masses at the humerus and ra...

Severe Multiple Cartilaginous Exostoses

Multiple cartilaginous exostoses (MCE) is one of the most common inherited skeletal disorders. A collection of 1124 cases was reported by Stock and Barrington (1925). Recently other large series have been published by Solomon (1963) and Sauer (1979). Different terms have been used for it such as multiple exostoses, hereditary multiple exostoses and diaphyseal aclasis. The swelling or "lump" are...

The Genetics of Hereditary Multiple Exostosis (HME)

Introduction Hereditary multiple exostosis (HME) is a skeletal disorder characterized by the presence of numerous bony outgrowths (osteochondromas or exostoses) that develop next to the growth plates of all the long bones (Solomon 1963). The most striking clinical feature of HME is the numerous cartilage-capped exostoses, which are associated with the entire skeleton. Skeletal surveys suggest t...